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A: Representative Western blot showing reduction in protein expression of STAT3 compared with control (C) using three unique siRNAs (1, 2, 3) targeted against STAT3. B: System A activity in control, siRNA STAT3 knockdown, and gAd-treated cells. Data are mean ± SEM for six placentas. Knocking down STAT3 significantly (RMANOVA, P = 0.002) reduced gAd stimulation of system A activity. Tukey-Kramer multiple comparisons post tests, **P < 0.01.
