. 2010 Feb 25;59(5):1171–1181. doi: 10.2337/db09-1402

TABLE 2.

Mixed M1/M2 remodeling transcriptional profiles in CD11c⁺ eATMΦs at HFD week 8

Gene	LFD	HFD	HFD	HFD
Gene	MGL1⁺/CD11c⁻	MGL1⁺/CD11c⁻	MGL1^med/CD11c⁺	MGL1⁻/CD11c⁺
M2
ARG-1	*	−*	↑*†	↑†
IL-1Ra	*	↑†	↑‡	↑‡
TGFβ−1	*†	↓*†	↓*†	↑*
PGC-1β	*	↑*	↑*	↑*
ADAM-8	*	↑†	↑‡	↑§
MMP-12	*	↑*	↑†	↑†
VEGF	*	↑*	↑†	↑‡
Clec7a	*	−*	↑*	↑*
IL-10	*†	↑*	↓†	↓‡
IL-13	*	↓*†	↓*†	↓†
Ym-1	*	−*	↓*	↓*
STAT-6	*	↑*	−*	−*
SPHK1	*	↓†	↓†	↓†
CD163	*	↓†	↓‡	↓‡
CD206	*	↓†	↓‡	↓‡
MMP-2	*	↓*†	↓†	↓†
M1
iNOS	*†	↑†	↓*	↓*
IL-1β	*	−*	↑†	↑†
IL12p40	*	↑*†	↑†	↑†
I-a	*†	↓*	↑†	↑‡
CCR2	*	↑†	↑†‡	↑‡
MCP-1	*	↓†	↓‡	↓‡
Caspase-1	*†	−*	↓†	↓*†
TLR4	*	−*	↓†	↓†
CD86	*	↓†	↓‡	↓‡
CD80	*	−*	−*	−*
STAT-1	*	−*	−*	−*

↓ and ↑ arrows indicate reduced or increased gene expression, respectively, as compared with MGL1⁺/CD11c⁻ eATMΦs from LFD-fed mice (n = 6) (see online appendix Fig. 2 for quantitative data summarized in this table). Transcript levels designated by different symbols are significantly different (P < 0.05, ANOVA and Tukey procedure).