FIG. 1.
Long-term HFD induces glucose intolerance and insulin resistance. A–D: Plasma (p)-glucose and insulin levels measured in mice fed ND (black traces and symbols) or HFD (gray traces and symbols) for 3 (A and B) and 15 (C and D) weeks during an IPGTT. Data are mean values ± SEM of n = 49 (A), n = 24 (B), n = 33 (C), and n = 14 (D). *P < 0.05, **P < 5 × 10−3, ***P < 5 × 10−4. E: Intraperitoneal insulin tolerance tests performed in 12-week-old mice (n = 23 in each group). The traces show means ± SEM. *P < 0.001 for comparisons between ND and HFD values.