TABLE 3.

Relative risk (95% CIs) of early versus late incident non-fatal MI, fatal CHD, and CABG/PCTA by tertiles of Lp-PLA₂ activity among 1,517 male and female diabetic subjects from the HPFS and NHS

	Tertiles of Lp-PLA2			P for trend
	1	2	3
Total CHD within 6 years (n = 1,517)	28	43	67
Age adjusted	1.0	1.70 (1.04–2.77)	2.41 (1.51–3.84)	<0.001
Multivariate adjusted*	1.0	1.72 (1.03–2.86)	2.34 (1.42–3.86)	<0.001
Multivariate adjusted + LDL	1.0	1.57 (0.93–2.65)	2.00 (1.16–3.44)	0.012
Total CHD after 6 years (n = 1,309)†	54	54	78
Age adjusted	1.0	1.10 (0.75–1.62)	1.65 (1.15–2.37)	0.005
Multivariate adjusted*	1.0	1.10 (0.73–1.63)	1.51 (1.02–2.23)	0.039
Multivariate adjusted + LDL	1.0	0.98 (0.65–1.47)	1.23 (0.81–1.89)	0.323

Results were pooled between men and women using inverse variance weights.

*Multivariate relative risks adjusted for age, fasting status, smoking, alcohol intake, physical activity, duration of diabetes, aspirin use, cholesterol-lowering medication use, family history of MI, history of hypertension, BMI, HDL, A1C, C-reactive protein, intercellular adhesion molecule, insulin use, waist circumference, estimated glomerular filtration rate, and hormone replacement therapy use (women only).

†Follow-up began 6 years after blood draw. Participants who sustained a nonfatal MI or fatal CHD or were lost to follow-up before year 6 were not considered at risk for a cardiovascular event after 6 years.