Fig. 2.

Caffeic acid phenethyl ester (CAPE) inhibits proliferation of human CD4⁺ T cells. CD4⁺ T cells (10⁶ cells/ml) were cultured for 48 h in the absence or presence of CAPE (10 µM) with soluble anti-CD3 and anti-CD28 monoclonal antibodies (2 µg/ml) stimulation. Tritiated thymidine [³H] incorporation for six healthy subjects and four asthmatic patients was measured by liquid scintillation counter and expressed as mean counts per minute (cpm). *P < 0·05; **P < 0·01.