TABLE I.

Immunosuppresion regimens

Immunosuppression regimen	Immunological Target	Specific use	Major adverse effects
Radiation, anti-metabolite agents	Hematopoietic Stem cells, Leukocytes	BMT	Cytopenias, opportunistic infections, diarrhea, alopecia, veno-occlusive disease, long-term organ damage: endocrine abnormalities, growth delay, hypodontia, cognitive delay, sterility
Calcineurin inhibitors, anti-lymphocyte antibodies, anti-cytokine antibodies, anti-metabolite agents and corticosteroids	Lymphocytes	In solid organ and BMT: prevention and treatment of graft rejection and of GVHD	Opportunistic infections, lymphopenia, renal dysfunction, seizures, hypertrichosis, hypertension, gastritis, osteoporosis, cataracts, growth delay