Fig. 2.

Distribution of ciliopathy-associated proteins among eukaryotes. Protein homologues were identified in 45 eukaryotic genomes, including 29 ciliated species and 16 non-ciliated species (grey). The presence of homologue(s) is indicated by a plus symbol (+). The proteins are grouped according to the ciliopathy (MKS, BBS and NPHP) or/and ciliary photoreceptor association. ‘Eye-associated’ proteins show a distribution that correlates with ciliary ‘c’ photoreceptors. The light blue shade indicates the exclusive presence of rhabdomeric ‘r’ photoreceptors.