Table 1.
Genes involved in the four major AM functions affected by Pneumocystis infection
| Gene | Pc vs. D | Immune Response (23 genes) | Inflammation (23 genes) | Cell Death (29 genes) | Phagocytosis (25 genes) |
|---|---|---|---|---|---|
| Lgals1 | -4.24 | ↓ | ↓ | ↓ | ↓ |
| Alcam | -2.29 | ↓ | ↓ | ↓ | ↓ |
| Cd55 | -1.68 | ↓ | ↓ | ↓ | ↓ |
| Cat | -1.64 | NA | NA | ↓ | ↓ |
| Hip1 | -1.63 | NA | NA | ↓ | ↓ |
| Hdac2 | -1.61 | NA | NA | ↓ | NA |
| Bnip3l | -1.58 | NA | NA | ↓ | NA |
| Nr1h3 | -1.52 | NA | NA | ↓ | NA |
| Ppp6c | -1.52 | NA | NA | ↓ | NA |
| Sod2 | 1.50 | ↑ | ↑ | ↑ | ↑ |
| Socs3 | 1.67 | ↑ | ↑ | ↑ | ↑ |
| Tap2 | 1.67 | NA | NA | ↑ | NA |
| Mmp14 | 1.78 | NA | ↑ | ↑ | ↑ |
| Prf1 | 1.78 | ↑ | ↑ | ↑ | ↑ |
| Il10 | 1.87 | ↑ | ↑ | ↑ | ↑ |
| Mmp7 | 1.92 | ↑ | ↑ | ↑ | ↑ |
| Mx2 | 1.94 | ↑ | NA | NA | ↑ |
| Sell | 1.97 | ↑ | ↑ | ↑ | ↑ |
| Psmb9 | 2.14 | ↑ | ↑ | ↑ | ↑ |
| Oas1a | 2.32 | ↑ | ↑ | ↑ | ↑ |
| Mmp8 | 2.34 | NA | ↑ | ↑ | ↑ |
| Clu | 2.37 | ↑ | ↑ | ↑ | ↑ |
| Ccr1 | 2.40 | ↑ | ↑ | ↑ | ↑ |
| Mx1 | 2.42 | ↑ | ↑ | ↑ | ↑ |
| Il8rb | 2.78 | ↑ | ↑ | ↑ | ↑ |
| Ccr5 | 2.79 | ↑ | ↑ | ↑ | ↑ |
| Gbp2 | 3.21 | ↑ | ↑ | NA | NA |
| Tap1 | 3.47 | ↑ | NA | NA | NA |
| Ccl5 | 3.58 | ↑ | ↑ | ↑ | ↑ |
| Irf7 | 4.92 | ↑ | ↑ | ↑ | ↑ |
| Nos2 | 6.35 | ↑ | ↑ | ↑ | ↑ |
| Cxcl10 | 12.33 | ↑ | ↑ | ↑ | ↑ |
Values shown are fold changes. Pc vs. D: expression affected by Pneumocystis (Pc) infection compared to the Dex (D) control. Up arrow (↑): up regulated by Pneumocystis infection; down arrow (↓): down regulated by Pneumocystis infection; NA: not applicable to the function.