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. 2010 Apr 21;5(4):e10189. doi: 10.1371/journal.pone.0010189

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Oshikawa et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Extracellular H₂O₂ generated by ecSOD localized at caveolae/lipid rafts via HBD induces oxidative inactivation of DEP1 and PTP1B in these microdomains, thereby promoting VEGF-induced VEGFR2 phosphorylation, which may contribute to EC migration and proliferation in vitro as well as angiogenesis in vivo.