Table 3.
Expression of Prx, association with patient and tumor characteristics.
| Characteristic | PrxI +/- |
PrxII +/- |
PrxIII +/- |
PrxIV +/- |
PrxV +/- |
PrxVI +/- |
|---|---|---|---|---|---|---|
| PATIENT | ||||||
| Age | ||||||
| Mean | 45.0/52.5 | 47.9/54.6 | 51.8/50.2 | #/50.9 | #/51.1 | 52.9/51.0 |
| Median | 39.8/54.4 | 45.6/56.3 | 54.1/51.9 | #/53.8 | #/53.9 | 56.8/53.5 |
| p = 0.014* | p = 0.005* | n.s. | n.s. | |||
| Sex | ||||||
| Male | 37/118 | 86/70 | 101/56 | 1/154 | #/156 | 13/139 |
| Female | 21/93 | 55/59 | 59/51 | -/110 | #/110 | 12/102 |
| n.s. | n.s. | n.s. | n.s. | n.s. | ||
| Recurrences | ||||||
| None | 42/193 | 117/118 | 136/96 | 1/229 | #/231 | 29/201 |
| ≥ 1 | 22/49 | 43/49 | 42/29 | -/71 | #/70 | 4/67 |
| p = 0.015** | n.s. | n.s. | n.s. | n.s. | ||
| Tumor proliferation (MIB-1) |
||||||
| Mean | ||||||
| SD | 13.8/16.9 | 16.2/16.5 | 17.5/15.2 | #/16.5 | #/16.4 | 11.1/16.8 |
| Median | 23.7/21.6 | 24.5/18.9 | 22.7/22.3 | #/22.2 | #/22.2 | 18.1/22.0 |
| 5.0/10.4 | 8.2/12.2 | 10.6/7.1 | #/9.4 | #/9.4 | 5.0/10.0 | |
| p = 0.019*** | n.s. | p = 0.056**** | p = 0.033*** | |||
| Tumor Apoptosis |
||||||
| Mean | 5.5/10.4 | 7.6/11.6 | 8.7/10.7 | #/9.6 | #/9.6 | 8.9/9.4 |
| SD | 12.1/15.9 | 12.7/17.9 | 13.5/18.0 | #/15.2 | #/15.2 | 14.2/15.6 |
| Median | 3.6/7.1 | 3.6/7.1 | 3.6/3.6 | #/3.6 | #/3.6 | 3.6/3.6 |
| p < 0.001*** | p = 0.007*** | n.s. | n.s. |
* T-test, only primary tumors were included
** Chi-square test
*** Mann-Whitney test
**** Near-significant p-value by Mann-Whitney test
# No cases in prx-positive group, analysis of significance not possible