Table 1.
Subgroups of up-regulated genes.
| Group | Group Size (probe sets) | Group Size (Genes) | NF-κB target genes (Bioinf) | NF-κB target genes (Lit) | ARE |
|---|---|---|---|---|---|
| IL-17 | 2 | 2 | - | - | - |
| TNF/IL-17 | 21 | 21 | 8 (38%) | 1 (5%) | 9 (43%) |
| IL1 + IL17 | 6 | 6 | - | - | - |
| IL1 + TNF | 141 | 135 | 23 (17%) | 8 (6%) | 24 (18%) |
| IL1 + TNF/IL17 | 89 | 80 | 9 (11%) | 18 (23%) | 15 (19%) |
| IL-17 + TNF/IL17 | 4 | 4 | - | - | - |
| IL17 + TNF | 4 | 4 | - | - | - |
| TNF + TNF/IL17 | 17 | 16 | - | - | - |
| TNF + IL1 + TNF/IL17 | 177 | 151 | 39 (26%) | 35 (23%) | 25 (17%) |
| TNF + IL17 + TNF/IL17 | 2 | 2 | - | - | - |
| IL1 + IL17 + TNF/IL17 | 12 | 10 | - | - | - |
| TNF + IL1 + IL17 | 14 | 14 | - | - | - |
| Up-regulated by all stimuli (TNF/IL-17, IL-17, TNF, IL-1) |
48 | 40 | 23 (58%) | 21 (53%) | 15 (38%) |
| All expressed genesa | 14.988 | 9.828 | 1369(14%) | 311 (3%) | 2076 (21%) |
Probe sets and gene numbers are indicated as well as frequency of NF-κB transcription factor binding site (separated for the bioinformatic and literature based approach) and the frequency of AU rich elements (ARE). Groups with less than 20 genes have been excluded from the analysis.
a This group comprises all genes which show at least one valid expression value