Table 1. Annotations of genes differentially expressed in wtSPZ compared to RAS.

Gene ID	Annotation	Features	Function	Fold change
PY01902	DEAD/DEAH box helicase		Multifunctional, unwinding of DNA double strand	1.79
PY04274	Homeobox-containing protein		Regulation of patterns of development during cellular morphogenesis	1.57
PY04964	Yir2 protein		Putative variable surface antigen	2.06
PY04970	1-deoxy-D-xylulose 5-phosphate synthase		Steroid biosynthesis	1.70
PY05197	Hypothetical protein			1.44
PY05422	Superoxide dismutases		Antioxidant defense	1.85
PY05941	Hypothetical protein			1.75
PY06056	Yir4 protein		Putative variable surface antigen	1.30
PY06378	Hypothetical protein			1.58
PY06476	Hypothetical protein	signal sequence and TM domain		1.77
PY06945	Rhoptry protein		Cellular invasion	1.77
PY07504	Hypothetical protein	signal sequence and TM domain		1.44

Annotations were obtained as described in methods. Fold change ratio of average gene expression in wtSPZ relative to RAS.

TM: Transmembrane domain, Yir: yoelii interspersed repeat.