Table 1.

Metabolic parameters

	LS Mean ± SEM			P
	EXE	EXE+ROSI	ROSI	EXE vs. EXE+ROSI	EXE vs. ROSI	EXE+ROSI vs. ROSI
n	45	47	45
HbA1C (%)
Baseline	7.8 ± 0.1	7.8 ± 0.1	7.9 ± 0.1
20 weeks	7.0 ± 0.1*	6.6 ± 0.1*	6.9 ± 0.1*
Change	−0.9 ± 0.1	−1.3 ± 0.1	−1.0 ± 0.1	0.016	0.720	0.039
Weight (kg)
Baseline	93.0 ± 2.4	93.8 ± 2.4	91.8 ± 2.4
20 weeks	89.7 ± 0.5*	91.3 ± 0.5*	94.0 ± 0.5*
Change	−2.8 ± 0.5	−1.2 ± 0.5	1.5 ± 0.5	0.038	<0.001	<0.001
Fasting glucose (mmol/l)
Baseline	8.42 ± 0.28	8.43 ± 0.27	8.48 ± 0.27
20 weeks	6.98 ± 0.25*	6.84 ± 0.24*	6.63 ± 0.25*
Change	−1.46 ± 0.25	−1.60 ± 0.24	−1.80 ± 0.25	0.693	0.331	0.555
Fasting insulin (μIU/ml)
Baseline	17.9 ± 2.0	13.8 ± 2.0	16.2 ± 2.0
20 weeks	16.3 ± 1.2	10.2 ± 1.2*	11.9 ± 1.2*
Change	0.2 ± 1.2	−5.9 ± 1.2	−4.2 ± 1.2	<0.001	0.011	0.316
Total fasting cholesterol (mmol/l)
Baseline	4.42 ± 0.15	4.41 ± 0.14	4.62 ± 0.15
20 weeks	4.33 ± 0.12	4.71 ± 0.11*	4.89 ± 0.12*
Change	−0.13 ± 0.12	0.26 ± 0.11	0.44 ± 0.12	0.020	<0.001	0.276
Fasting HDL (mmol/l)
Baseline	1.13 ± 0.05	1.17 ± 0.05	1.17 ± 0.05
20 weeks	1.16 ± 0.03	1.19 ± 0.03	1.20 ± 0.03
Change	0.02 ± 0.03	0.05 ± 0.03	0.06 ± 0.03	0.566	0.445	0.840
Fasting LDL (mmol/l)
Baseline	2.59 ± 0.13	2.57 ± 0.13	2.71 ± 0.13
20 weeks	2.55 ± 0.10	2.69 ± 0.10	2.93 ± 0.10*
Change	−0.05 ± 0.10	0.10 ± 0.10	0.33 ± 0.10	0.308	0.008	0.096
Fasting triglycerides (mmol/l)
Baseline	1.77 ± 0.19	1.82 ± 0.18	2.14 ± 0.18
20 weeks	1.59 ± 0.17*	1.94 ± 0.16	2.01 ± 0.17
Change	−0.34 ± 0.17	0.00 ± 0.16	0.07 ± 0.17	0.140	0.079	0.752

*P < 0.05 from baseline.