Table 1.
Phase-II enzyme activity, glutathione and TBARS in the liver of P.berghei-infected mice
| Parameters | GST | UGT | GSH | TBARS | ||
|---|---|---|---|---|---|---|
| Sub-cellular fraction | m | c | m | c | - | |
| DBA-2 | Infected (N) |
80.4 ± 4.5 (8) |
700 ± 100 (8) |
8.4 ± 3.2 (8) |
86.0 ± 8.0 (7) |
13.5 ± 3.9 (5) |
| Control (N) |
91.0 ± 5.4 (8) |
800 ± 100 (8) |
9.0 ± 3.0 (8) |
76.9 ± 9.0 (7) |
39.0 ± 5.5* (5) |
|
| C57BL/6 | Infected (N) |
85.6 ± 6.1 (8) |
1 400 ± 100 (6) |
7.4 ± 3.7 (9) |
35.0 ± 9.8 (6) |
19.5 ± 2.7 (5) |
| Control (N) |
95.9 ± 2.7 (8) |
1 500 ± 100 (8) |
5.5 ± 3.0 (9) |
16.9 ± 8.6* (8) |
23.6 ± 12.3 (5) |
|
Data are mean ± S.E.M. m: microsomal fraction; c: cytosolic fraction; (N): number of animals. Values different from those for non-infected controls (Student's t test, P < 0.05) are indicated by an asterisk (*). Enzyme activities are expressed as nmol/mg ptn/min (mGST and UGT) and μmol/mg ptn/min (cGST). GSH as nmol/mg ptn; TBARS as nmol MDA/g wet tissue.