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| Kmapp ATP (μM) | Kmapp peptide (μM) | kcat (min-1) | [Mn2+] (mM) | IC50 lapatinib (μM) | Kiapp lapatinib (nM) | |
|---|---|---|---|---|---|---|
| ErbB4 KD | 10 ± 2 | 169 ± 35 | 52 ± 10 | 2 | 1.4 ± 0.1 | 700 |
| ErbB2 KD | 24 ± 3 | 57 ± 5 | 6.1 ± 0.2 | 10 | -- | - |
| EGFR ICD* | 5 | 899 ± 200 | 1.32 | 0.62 | -- | 3 ± 0.2 |
| ErbB2 ICD* | 13 | 157 ± 40 | 3.60 | 1.60 | -- | 13 ± 1 |
| ErbB4 ICD* | 21 | 144 ± 22 | 5.58 | 0.20 | > 1 | 347 ± 16 |
These are previously reported values. (Brignola et al. 2002 and Wood et al. 2004).
