Figure 2. Biological ligands of PPARα.

Diagram illustrating different known biological ligands of PPARα. Metabolic sources for ligands are grouped in the boxes together with ligand generating enzymes marked with an asterisk, ligands marked with a square and ligand degrading enzymes marked with a triangle. The PPARα and RXRα heterodimer are shown bound to a PPRE sequence in the promoter of a target gene with associated coactivator proteins forming a complex with the cellular transcription machinery.