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. 2010 Apr 16;8:e003. doi: 10.1621/nrs.08003

Figure 5. DamIP identifies indirect regulation by ER.

Figure 5

ER can regulate gene expression through long range chromosome looping (A, B) or binding with other transcriptional factors (C). Carbonic anhydrase XII (C12) and cathepsin D (CTSD) enhancers contain functional EREs but not promoter regions, however, DamIP indicates ER communicates with the ERE-less promoter regions during transcription. ER regulation through interaction with AP1 (C, left panel) or Sp1 (C, right panel) can also be detected by DamIP.