Figure 3.
Cell cycle–related genes are up-regulated in HPV+ cancers. A, highly up-regulated genes in HPV+ cancers were analyzed by GO grouping. Cell cycle–related genes were selected and plotted on the heat map. Blue bars, HPV− cervical cancers. B, up- and down-regulated genes indicated in the cell cycle pathway provided by the KEGG database. Red and blue boxes, up-regulated genes in HPV+ and HPV− cancers compared with corresponding normal tissue, respectively. C, a part of the cell cycle–related genes was analyzed using qRT-PCR. Fold changes of the gene expression in NIKS-16 relative to gene expression in NIKS. Columns, mean; bars, SD.