Table 2.

Cervical histopathology summary for Rb^WT and Rb^ΔL mice

	NH	CIN1	CIN2	CIN3	CIS	MIC	LIC
RbWT/WT	14	1
K14E7RbWT/WT				5	4	4	1
RbΔL/ΔL	11	1
K14E7RbΔLΔL	6	2				4

NOTE: Criteria for diagnosis are described in Materials and Methods. Each number indicates the number of mice of the indicated genotype for which the indicated lesion is the worst cervical lesion detected. Note that all K14E7Rb^WT/WT mice developed multiple CIN2 and CIN3 lesions. The lack of CIN2 and CIN3 in K14E7Rb^ΔL/ΔL mice is significant compared with K14E7Rb^WT/WT mice (P < 0.0001). The incidence of invasive cancers in K14E7Rb^ΔL/ΔL mice is significantly higher than in control mice (P < 0.05) and similar to that in K14E7Rb^WT/WT mice (P = 0.555).