FIG. 5.

(A) Distribution of CD4⁺ and CD8⁺ T cell subsets as defined by total naive or memory cells with horizontal lines representing medians and interquartile ranges (25th and 75th percentiles) in a group of untreated HIV-positive Ugandan adults (N = 27). The median distributions of memory phenotypes on CD4⁺ and CD8⁺ T cells were 76% and 55%, respectively. (B) Immune activation in CD4⁺ and CD8⁺ T cell subsets. Naive and memory T cell activation was defined as the percentage of CD45RA⁺CD27⁺ or CD45RA⁻CD27^+/− cells expressing HLA-DR and CD38, respectively. Median naive and memory CD4⁺ T cell activation was 22% and 2%, respectively. Median naive and memory CD8⁺ T cell activation was 53% and 21%, respectively.