Table 3.
Effect of time since last use and duration of hormone replacement therapy on risk of hip fracture
| Use of hormone replacement therapy | Any
|
Without progestin
|
With progestin
|
|||||
|---|---|---|---|---|---|---|---|---|
| No of cases/ controls | Odds ratio* | No of cases/ controls | Odds ratio* | No of cases/ controls | Odds ratio* | |||
| (95% CI) | (95% CI) | (95% CI) | ||||||
| Never used | 956/2073 | 1.00 (reference) | 956/2073 | 1.00 (reference) | 956/2073 | 1.00 (reference) | ||
| Last use ⩽12 months: | ||||||||
| Any use | 47/260 | 0.38 (0.26 to 0.56) | 21/70 | 0.61 (0.35 to 1.04) | 28/198 | 0.28 (0.17 to 0.47) | ||
| Total use >5 years | 14/97 | 0.28 (0.16 to 0.51) | 8/36 | 0.35 (0.15 to 0.82) | 9/66 | 0.24 (0.11 to 0.52) | ||
| Per year of use | 0.92 (0.88 to 0.96) | 0.93 (0.88 to 0.98) | 0.88 (0.82 to 0.95) | |||||
| Last use 13-60 months: | ||||||||
| Any use | 11/45 | 0.52 (0.26 to 1.04) | 9/23 | 0.82 (0.37 to 1.84) | 7/31 | 0.42 (0.17 to 1.04) | ||
| Total use >5 years | 3/18 | 0.27 (0.08 to 0.94) | 3/6 | 0.65 (0.14 to 3.05) | 1/12 | 0.10 (0.01 to 0.87) | ||
| Per year of use | 0.91 (0.82 to 1.00) | 0.97 (0.86 to 1.09) | 0.78 (0.63 to 0.97) | |||||
| Last use >60 months: | ||||||||
| Any use | 46/125 | 0.75 (0.52 to 1.07) | 38/115 | 0.65 (0.44 to 0.96) | 17/38 | 1.00 (0.55 to 1.82) | ||
| Total use >5 years | 15/28 | 1.07 (0.57 to 2.03) | 12/22 | 1.06 (0.52 to 2.19) | 3/8 | 0.74 (0.19 to 2.93) | ||
| Per year of use | 0.98 (0.92 to 1.04) | 0.98 (0.91 to 1.05) | 0.96 (0.83 to 1.12) | |||||
*
Adjusted for age (50 to 54, 55 to 59, 60 to 64, 65 to 69, 70 to 74, 75 to 81 years) and the indication of hormone replacement therapy to prevent osteoporosis (yes/no).