TABLE 2B.
Distribution of Monocyte Subpopulations
| Animal subgroup | CD4 T cells (μL) | CD4/CD8 ratio | Viral load (copies/mL) | Monocytes (%) | Monocytes (μL) | CD14highCD16– (μL) | CD14highCD16low (μL) | CD14lowCD16high (μL) | M2/M1 ra tio | M3/M1 ratio | (M2+M3)/ M1 ratio |
|---|---|---|---|---|---|---|---|---|---|---|---|
| n=14 Monkeys with VL <70,000 (median) | |||||||||||
| median (range) | 634 | 0.66 | 10,950 | 5.1 | 295 | 163 | 21 | 24 | 0.18 | 0.16 | 0.31 |
| (17–1275) | (0.07–1.37) | (270–68,000) | (2.6–9.2) | (150–560) | (62–318) | (10–92) | (4–65) | ||||
| n=12 Monkeys with VL >70,000 (median) | |||||||||||
| median (range) | 851 | 0.71 | 225,000 | 6.3 | 565a | 281 | 111b | 65a | 0.38a | 0.29 | 0.60c |
| (178–1653) | (0.17–1.18) | (70,000–16,000,000) | (4.1–12.5) | (280–1430) | (123–393) | (53–293) | (34–95) |
Animals with detectable plasma virus RNA are subdivided into two subgroups: one with low viral load (<median, 70,000 copies/ml); and one with high viral load (>70,000 copies/ml). Comparison of animals with high viral load vs. animals with low viral load performed with the Wilcoxon test. Significance at **, P < 0.01; ***, P < 0.001, and ****, P < 0.0001.