Figure 2.

CD11b⁺Gr1⁺ cells expand in the liver of mice with PanIN lesions. Mice expressing a single mutant Kras allele in the progenitor cells of the pancreas develop a stepwise progression from normal pancreatic parenchyma with organized acinar cell (AC) architecture to preinvasive pancreatic cancer. Sporadic, early PanIN lesions are evident at 3 months, followed by complete replacement of acinar tissue with PanIN lesions by 9 months. Progression of the disease is accompanied by a large stromal reaction (Str). In livers of LSL-Kras^G12D mice, there is a gradual expansion of the CD11b⁺Gr1⁺ population. These data are representative of experiments repeated more than three times using two to four mice/time-point. M.