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. Author manuscript; available in PMC: 2010 Apr 22.
Published in final edited form as: Pharmacol Biochem Behav. 2008 Aug 23;91(2):261–270. doi: 10.1016/j.pbb.2008.08.018

Table 2.

Levels of P4 (top) and DHP (bottom) in the midbrain, hippocampus, striatum, and cortex of ovariectomized rats administered subcutaneous (SC) vehicle+Intra-VTA vehicle, SC E2+ Intra-VTA vehicle, SC vehicle+Intra-VTA 3α,5α-THP, or SC E2+Intra-VTA 3α,5α-THP

Experimental condition Central concentrations
Midbrain Hippocampus Striatum Cortex
P4 (ng/g)
SC vehicle+Intra-VTA vehicle 2.1±0.2 1.3±0.2 1.6±0.2 1.3±0.2
SC E2+Intra-VTA vehicle 1.7±0.1 1.1±0.2 1.2±0.1 2.0±0.2
SC vehicle+Intra-VTA 3α,5α-THP 1.5±0.1 1.2±0.1 1.3±0.1 1.7±0.1
SC E2+Intra-VTA 3α,5α-THP 2.2±0.1 1.6±0.1 1.6±0.1 1.9±0.2
DHP (ng/g)
SC vehicle+Intra-VTA vehicle 1.9±0.7 0.6±0.1 0.6±0.2 1.5±0.2
SC E2+Intra-VTA vehicle 2.6±0.9 1.8±0.9 1.8±0.4 0.9±0.1
SC vehicle+Intra-VTA 3α,5α-THP 2.3±0.6 0.5±0.1 1.0±0.7 1.4±0.5
SC E2+Intra-VTA 3α,5α-THP 1.3±0.3 1.9±0.8 0.8±0.2 1.5±0.9