Table 3.

Distribution of Neuropathological Markers

Cases	Age at Death (yr)	NFT Neocortex			NFT Entorhinal	Neuritic Plaques Neocortex
			Left	Right			Left	Right
PPA/AD Case 1	73	F	+++	++	+++	F	+++	+++
		T	+++	+++		T	+++	+++
		P	+++	+++		P	+++	+++
PPA/AD Case 2	59	F	+++	+++	+++	F	+++	+++
		T	+++	+++		T	+++	+++
		P	+++	+++		P	+++	+++
PPA/AD Case 3	72	F, T, P	2.73	1.70	30.96	F	++	+++
						T	+++	+++
						P	++	++
PPA/AD Case 4	76	F, T, P	6.67	2.75	50.39	F	+++	+++
						T	+++	+++
						P	+++	+++
PPA/AD Case 5	73	F, T, P	3.82	1.64	21.84	F	+++	+++
						T	+++	+++
						P	+++	+++
PPA/AD Case 6	78	F	+++	+++	+++	F	+++	+++
		T	+++	+++		T	+++	+++
		P	+++	+++		P	+++	+++
PPA/AD Case 7	71	F	+++	++	+++	F	+++	++
		T	+++	+++		T	+++	+++
		P	+++	+++		P	+++	+++
PPA/AD Case 8	78	F	+++	+++	+++	F	+++	++
		T	+++	+++		T	+++	+++
		P	+++	+++		P	+++	+++
PPA/AD Case 9	70	F, T, P	1.55	1.44	29.95	F	+	++
						T	+++	+++
						P	+++	+++
PPA/AD Case 10	68	F	+++	+++	+++	F	+++	+++
		T	+++	+++		T	+++	+++
		P	+++	+++		P	+++	+++
DAT/AD Case 1	72	F, T, P	3.93	3.38	35.02
DAT/AD Case 2	79	F, T, P	1.52	0.78	39.43
DAT/AD Case 3	58	F, T, P	5.23	4.75	20.83
DAT/AD Case 4	78	F, T, P	1.39	2.59	23.85

In the 10 primary progressive aphasia/Alzheimer’s disease (PPA/AD) cases where tissue was available, neurofibrillary tangles (NFT) and neuritic plaques were assessed qualitatively and rated as sparse (+), moderate (++), or frequent (+++) in the inferior frontal gyrus (F), inferior parietal lobule (P), and superior temporal gyrus (T) according to established Consortium to Establish a Registry for Alzheimer’s Disease (CERAD)–based neuropathological criteria.⁵⁵ NFT numbers in Cases 3, 4, 5, and 9 and in the four dementia of the Alzheimer type (DAT)/AD cases are given per cubic millimeter. These were the only cases where multiple serially cut sections through the relevant areas were available in thioflavin-S–stained preparations suitable for stereology. Quantitative neocortical counts reflect the average derived from the inferior frontal gyrus, superior temporal gyrus, and inferior parietal lobule sections (F, T, P). The entorhinal densities reflect an average of the two sides. Within the set of stereologically analyzed cases, the qualitative ratings (data not shown) showed asymmetry only in Case 3 and only in the inferior frontal gyrus (++ in the right, +++ in the left). Although the stereologically determined neocortical NFT counts appear low, they represent densities per cubic milllimeter and are all in the high +++ range of qualitative assessment.