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. Author manuscript; available in PMC: 2010 Apr 22.
Published in final edited form as: Neurosci Biobehav Rev. 2009 Jan 21;33(5):699–771. doi: 10.1016/j.neubiorev.2009.01.004

Table 24.

Volumetric Changes of Dorsal PFC in MDD.

Study Sample Age Method Age of
Onset		 Illness
Duration/#
Episodes		 Family
History of
Illness		 Clinical
Status at
Testing		 Medication Status Psychiatric Comorbidity Findings Brodmann
Map/Stereotaxic
Coordinates
(Shah et al 1998) 20 MDD (chronic)
20 MDD (remitted)
20 HC		 21–65 VBM NR NR NR Depressed and remitted AD No mania, significant substance abuse, organic pathology or neurological illness Reduced GM volume of L DLPFC chronic MDD −56; 1; 32
(Chen et al 2007a) 17 MDD 44.06±8.36 MRI
1.5T
3mm		 NR NR NR Depressed Scanned before and after treatment with fluoxetine. Patients off medication 4+ weeks before study. No current axis I comorbidity or substance abuse within 2 months of study. Personality disorders not assessed. Severity of depression negatively correlated with GM volume of DLPFC. BA 46
31; 53; 15
−31; 45; 17
BA 9
32; 34; 30
−15; 35; 42