Table 1. SUPREX Data and Screening Efficiency for CypA.
| Fragment number |
Molecular Weight (Da) |
C1/2SUPREX (M, GdmCl) |
SUPREX Curve Amplitude (Da) |
Average Standard Deviation (Da)a |
Z’-Factor | False Positives |
False Negatives |
|---|---|---|---|---|---|---|---|
| 1 | 1623 | 1.9 | 2.5 | 0.3 | 0.4 | 0 | 0 |
| 2 | 1865 | 1.9 | 3.8 | 0.3 | 0.4 | 0 | 0 |
| 3 | 2375 | 1.6 | 2.6 | 0.4 | 0.4 | 0 | 0 |
| 4 | 2427 | 1.6 | 1.6 | 0.3 | 0.2 | 0 | 0 |
| 5 | 2574 | 1.6 | 1.9 | 0.3 | 0.1 | 0 | 0 |
| 6 | 2671 | 1.7 | 1.5 | 0.4 | -0.2 | 0 | 1/30 (3%) |
| 7 | 2742 | 1.7 | 1.8 | 0.3 | -0.2 | 0 | 0 |
| 8 | 2839 | 1.6 | 3.9 | 0.3 | 0.4 | 0 | 0 |
| 9 | 3083 | 1.9 | 3.7 | 0.3 | 0.2 | 0 | 0 |
| 10 | 6046 | 2.1 | 5.8 | 0.7 | -0.9 | 3/30 (10%) | 0 |
a
This value is the average of the standard deviations of the mass measurements from each point in a representative SUPREX curve.