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. 2010 Feb 1;115(15):3162–3165. doi: 10.1182/blood-2009-08-236943

Figure 1.

Figure 1

Influence of donor KIR3DS1 on HSCT outcomes. (A) Incidence of grade II-IV acute GVHD (aGVHD) based on donor KIR3DS1 copy number and presence/absence of recipient HLA-Bw4 KIR epitope. Grade II-IV aGVHD was lower among HLA-Bw4+ recipients with a KIR3DS1+ donor. Donor KIR3DS1 homozygosity is associated with the lowest rate of grade II-IV aGVHD (39%). (B) Probability of TRM stratified by donor KIR3DS1 copy number. TRM is similarly affected by donor KIR3DS1 copy number; the lowest TRM is associated with donor KIR3DS1 homozygosity (31%, P = .02). (C) Kaplan-Meier survival analysis demonstrating an association of overall survival with donor KIR3DS1 copy number (P = .03). (D) There is no association of donor KIR3DS1 with risk of relapse (P = .82).