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GTP sensitive agonist binding: Membranes from WT and VGV/Y. Gpp(NH)p (200 μM) was added to assay buffer containing 1 nM [125I]-DOI to eliminate high affinity binding; the [125I]-DOI binding in the absence and presence of Gpp(NH)p is plotted. Membranes from VGV/Y show no detectable GTP-sensitive [125I]-DOI binding to 5-HT2C receptors. A significant effect of genotype was observed (F1,43 = 54.66, p < 0.0001).
