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SB206553 increases DA and 5-HT turnover in VGV/Y mice. (A) DA turnover (DOPAC/DA) following administration of saline or SB206553 (3 mg/kg) in WT (▲) and VGV/Y (•) mice; cortex (left), striatum (right). (B) HVA/DA and (C) 5-HT turnover (5-HIAA/5-HT) after the same conditions. Significant genotype by drug interactions were observed for the ratio DOPAC/DA (F1,16 = 20.39, p = 0.0004), for HVA/DA (F1,16 = 8.10, p = 0.0117) and for 5-HlAA/5-HT (Fl,16 = 19.42, p = 0.0004).
