Figure 7.
5-HT2C receptor density in WT, VGV/X, and VGV/Y mice. Mesulergine saturation binding analyses are shown for VGV/Y and VGV/X mice (A), and WT mice (B), The data are means of triplicate determinations and represent four to eight separate experiments. Mean values were as follows. Bmax (fmol/mg protein) ± SEM: VGV/ Y, 4266 ± 259.9 **(p < 0.001 compared to WT and VGV/ X); VGV/X, I754 ± 149 *(p < 0.001 compared to WT); WT, 163.3 ± 5.9. Kd (nM) ± SEM: VGV/Y. 3.18 ± 0.23; VGV/X, 2.49 ± 0.30; WT, 2.13 ± 0.26. Differences between means were determined by a one-way ANOVA followed by a Tukey test.