Figure 4.

Properties of MMCs were similar in colon segments from WT and P2X2 and P2X3 KO mice. (A) The frequency of colonic MMC was increased in colonic segments from P2X2 but not P2X3 subunit KO mice when compared to WT colonic segments (P < 0.05). (B) The velocity of colonic MMC propagation was not altered by P2X2 or P2X3 subunit KO mice. The amplitude of contractions at the oral end (C) or anal end (D) of colonic segments was not altered by P2X2 or P2X3 subunit KO (P > 0.05). Data are mean ± SEM. Data analyzed by the Kruskal–Wallis and Dunn non-parametric multiple comparisons tests.