Table 2.
Univariable comparisons between those with and without dipstick proteinuria.
| Variable | ACTG 384 | ACTG A5095/ALLRT | ||||
|---|---|---|---|---|---|---|
| Dipstick proteinuria ≥ 1+ | Dipstick proteinuria ≥ 1+ | |||||
| Yes N=39 (7%) | No N=537 (93%) | P | Yes N=34 (8%) | No N=402 (92%) | P | |
| %CD8+/CD38+/HLA-DR+ | 57 (45, 69) | 48 (37, 60) | 0.005 | 52 (42, 70) | 52 (37, 64) | 0.42 |
| Age, yrs | 36 (32, 41) | 35 (30, 43) | 0.67 | 38 (34, 45) | 37 (32, 43) | 0.22 |
| Sex, no. male (%) | 30 (77%) | 446 (83%) | 0.39 | 30 (88%) | 343 (85%) | 0.80 |
| Body mass index, kg/m2 | 24.9 (21.9, 29.8) | 24.6 (22.1, 27.9) | 0.70 | 24.0 (21.4, 27.1) | 24.7 (22.0, 27.6) | 0.57 |
| Race/ethnicity, no. (%) | 0.056 | 0.003 | ||||
| Black, non-Hispanic | 24 (62%) | 195 (36%) | 18 (53%) | 109 (27%) | ||
| White, non-Hispanic | 12 (31%) | 257 (48%) | 7 (21%) | 199 (50%) | ||
| Hispanic | 3 (8%) | 79 (15%) | 8 (24%) | 86 (21%) | ||
| CD4 cell count/μL | ||||||
| Median | 164 (37, 264) | 288 (117, 460) | 0.0002 | 123 (27, 286) | 250 (116, 383) | 0.005 |
| <200, no. (%) | 25 (64%) | 190 (35%) | <0.001 | 21 (62%) | 159 (40%) | 0.017 |
| Log10 HIV-1 RNA/mL | 5.39 (4.78, 5.74) | 4.91 (4.33, 5.51) | 0.016 | 5.27 (4.70, 5.75) | 4.74 (4.36, 5.30) | 0.001 |
| Hemoglobin, g/dL | 11.9 (11.1, 13) | 13.8 (12.6, 15.0) | <0.001 | 13.1 (11.3, 14.2) | 13.8 (12.5, 14.8) | 0.005 |
| Hypertension, no. (%) | 3 (8%) | 33 (6%) | 0.73 | 4(12%) | 32 (8%) | 0.51 |
| Diabetes, no. (%) | 1 (3%) | 8 (1%) | 0.47 | 2 (6%) | 14 (3%) | 0.36 |
| Viral hepatitis co-infection, no. (%) | 4 (11) | 34 (6) | 0.31 | 7 (21) | 61 (15) | 0.46 |
| Creatinine clearance <90mL/min, no. (%) | 12 (31%) | 92 (17%) | 0.05 | 8 (23%) | 64 (16%) | 0.24 |
Note. All values are presented as median (interquartile range) unless otherwise specified.