Table 4.
Univariable comparisons between those with and without creatinine clearance less than 90mL/min.
| Variable | ACTG 384 |
ACTG A5095/ALLRT |
||||
|---|---|---|---|---|---|---|
| Creatinine clearance <90mL/min | Creatinine clearance <90mL/min | |||||
| Yes N=119 (19%) | No N=496 (81%) | P | Yes N=76 (17%) | No N=380 (83%) | P | |
| %CD8+/CD38+/HLA-DR+ | 53 (38, 64) | 48 (37, 59) | 0.04 | 51 (38, 66) | 53 (37, 64) | 0.82 |
| Age, yrs | 42 (36, 51) | 35 (29, 41) | <0.01 | 41 (35, 51) | 37 (32, 42) | <0.01 |
| Sex, no. male (%) | 93 (78) | 414 (83) | 0.17 | 60 (79) | 329 (87) | 0.09 |
| Weight, kg | 64.2 (57.5, 71.4) | 76.7 (68.9, 88.3) | <0.01 | 61.3 (56.6, 68.3) | 77.6 (68.5, 86.4) | <0.01 |
| Race/ethnicity, no. (%) | ||||||
| Black, non-Hispanic | 61 (51) | 179 (36) | 0.01 | 28 (37) | 104 (27) | 0.03 |
| White, non-Hispanic | 40 (34) | 239 (48) | 32 (42) | 186 (49) | ||
| Hispanic | 15 (13) | 69 (14) | 12 (16) | 85 (22) | ||
| CD4 cell count/μL | ||||||
| Median | 223 (60, 398) | 287 (117, 458) | 0.03 | 152 (52, 303) | 247 (117, 394) | <0.01 |
| <200, no. (%) | 55 (46) | 172 (35) | 0.02 | 42 (55) | 150 (39) | 0.01 |
| Log HIV-1 RNA/mL | 5.00 (4.29, 5.54) | 4.90 (4.33, 5.51) | 0.53 | 4.86 (4.47, 5.49) | 4.73 (4.37, 5.32) | 0.19 |
| Hemoglobin, g/dL | 13.2 (11.9, 14.2) | 13.8 (12.6, 15.0) | <0.01 | 13.3 (11.9, 14.3) | 13.8 (12.6, 14.8) | <0.01 |
| Hypertension, no. (%) | 11 (9) | 27 (5) | 0.12 | 9 (12) | 28 (7) | 0.19 |
| Diabetes, no. (%) | 2 (2) | 7 (1) | 0.83 | 1 (1) | 15 (4) | 0.26 |
| Viral hepatitis co-infection, no. (%) | 10 (8) | 30 (6) | 0.41 | 13 (17) | 54 (14) | 0.48 |
| Proteinuria ≥ 1+, no. (%) | 12 (12%) | 27 (6%) | 0.05 | 8 (11%) | 26 (7%) | 0.24 |
Note. All values are presented as median (interquartile range) unless otherwise specified.