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. 2010 Apr 22;5(4):e10302. doi: 10.1371/journal.pone.0010302

Figure 1. Schematic of human COMP showing shRNA target locations relative to mRNA structure and protein domains.

Figure 1

Solid gray blocks are used to indicate the 5′UTR, coding region and 3′UTR of COMP mRNA. The positions of COMP protein domains including the pentamer, epithelial growth factor (EGF)-like, type 3 calcium repeat and globular domains are shown below the protein structure. The position of the common D469del mutation in exon 17B is designated by arrow. Stem-loop hairpins indicate target positions of the shRNAs.