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. 2010 Apr 22;6(4):e1000917. doi: 10.1371/journal.pgen.1000917

Figure 4. Nucleosome eviction is a frequent occurrence at L1 promoters.

Figure 4

Partial MNase digestion of nucleosomes was followed by fractionation by a sucrose density gradient. When a Southern for genomic DNA was performed on the DNA in each fraction (6–16), enrichment in the mono- and dinucleosome fractions was revealed. When a Southern for L1s was performed enrichment of L1s in the di- and tetranucleosome fractions was found. According to our model the L1 promoters with a tetranucleosomal structure should be inactive and methylated.