Figure 4.

Pharmacological inhibition of CysLT generation and function blocks the effects of eotaxin and IL-13. Data (mean±sem, n=3) are the numbers of EPO+ cells present by Day 7 in 1 mL liquid cultures established with IL-5 (1 ng/ml), alone or in association with the indicated concentrations of IL-13, eotaxin, and drugs targeting 5-LO (Zil, zileuton, A), FLAP (MK886, B), or CysLT1R (Mkt, montelukast, C). *, P < 0.05, for the differences between the indicated points and the respective IL-5 (negative) controls.