Figure 5.

Effect of mutations preventing CysLT generation on the responses to eotaxin and IL-13. Data (mean±sem, n=3) are the numbers of EPO+ cells/ml present by Day 7 in liquid culture established with IL-5 (1 ng/ml), alone or in association with the indicated concentrations of IL-13, eotaxin, or LTD4 from bone marrow of wild-type (WT) control mice (A, S129; B, BALB/c) or mutant mice [A, 5-LO (−/−); B, LTC4s (−/−)]. *, P < 0.05, for the differences between the indicated points and the respective IL-5 (negative) controls.