TABLE 1.

Summary of Kinetic Parameters of Transport of Chloride in Neutrophil Phagosomes of Normal and CF Neutrophils^a

	Extracellular medium change from 0 mM to 135 mM CI−		Extracellular medium change from 135 mM to 0 mM Cl−
	Initial influx rate mM/s	Steady-state [Cl−]PL (mM)	Initial efflux rate mM/s	Steady-state [Cl−]PL (mM)
Normal controls (n = 5)	0.31 ± 0.04	67.7 ± 7.3	−0.26 ± 0.05	15.9 ± 4.3
Normals GlyH-101 (n = 5)	0.013 ± 0.067b	27.7 ± 4.4b	−0.095 ± 0.022c	12.9 ± 4.2
CF (n = 5)	0.043 ± 0.012b	25.5 ± 3.3b	−0.063 ± 0.13c	17.0 ± 3.3

^aThe influx rate represents the maximal initial slope of the chloride change in mM/s after changing the medium from NaGlu R (0 mM chloride) to NaCl R (135 mM chloride) at the 10-min mark. The efflux rate represents the opposite rate (hence, indicated by negative signs) when the buffer was changed from NaCl R (135 mM chloride) to NaGlu R (0 mM chloride) at the 20-min mark. The steady-state [Cl⁻]_PL represents the phagosomal chloride level 10 min after each respective buffer change. 

^bP < 0.001; 

^cP < 0.05 by Wilcoxon-Mann-Whitney nonparametric analysis (each was compared with the corresponding normal controls). [Cl⁻]_PL, phagosomal chloride concentration.