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. 2010 Apr 22;6(4):e1000756. doi: 10.1371/journal.pcbi.1000756

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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For a rapidly metabolized compound (upper curve) variability in exposure causes some apoptosis in the spatially-extended lobule. The shaded region indicates the 95% interval.