Table 3. Parameters Used for PBPK Model.

Parameter	Value	Source
Qcard	336 L/h	[43]
Qgut	66 L/h	[43]
Qliv	18 L/h	[43]
Qgfr	7.5 L/h	[43]
Qrest	252 L/h	[43]
Bodyweight	70 kg	assumed
Lean Fraction of BW	0.7	[19]
Vart, Vven	0.025 L/kg lean bw	[19]
Vgut	0.0165 L/kg bw	[19]
Vliv	0.035 L/kg lean bw	[19]
Vlung	0.27 L	[44]
Vrest	0.6 L/kg bw – (Vart+Vven+Vgut+Vliv+Vlung)	[43]
kad, kinh, Krest∶plas, Kliv∶plas, Kgut∶plas, Rblood∶plas, f	1	assumed