Table 3.

Protective effect of polymorphisms in the genes of IL12A and its receptor, IL12RB1, against severe malaria anaemia

	Severe malaria anaemia episodes crude incidence/1000 person-months			Adjusted risk ratio (95% CI)a
IL12 A-rs2243140b	TT	TC	CC	CC vs TT	TC vs TT	P
	12.2	7.7	0	0.28 (0.10-0.79)	0.52 (0.31-0.89)	.006
IL12RB1-rs429774c	TT	TC	CC	CC vs (TT+TC)		P
	12.2	11.2	2.8	0.18 (0.05-0.69)		.00005

NOTE.

^a Adjusted by sickle cell type and treatment with anti-malarial drugs.

^b An additive genetic model used for IL12A-rs2243140, which treats the marker as a continuous variable and is extrapolated based on Poisson model.

^c A dominant model used for the second marker, IL12RB1-rs429774.