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. Author manuscript; available in PMC: 2010 Jun 2.
Published in final edited form as: Circulation. 2009 May 18;119(21):2789–2797. doi: 10.1161/CIRCULATIONAHA.108.822403

Figure 2. Cross-sectional study of cardiac pathology.

Figure 2

A) Old WT (OWT) mice had larger myocardial fiber width than old mCAT (OmCAT) mice (trichrome stain, 400x, scale bar:10μm). B) Quantitative analysis showed a significant increase in myocardial fiber-width in aged heart, which was significantly attenuated in OmCAT mice. C) OWT mice had more fibrosis (blue; trichrome , 20x) than OmCAT mice, as shown by quantitative image analysis of the percent fibrotic area in aged hearts, which was significantly attenuated in OmCAT mice (D).