Table 2.
Statin effects
| Visit 1 (statin) | Visit 2 (no statin) | Visit 3 (statin) | |
|---|---|---|---|
| MSNA (bursts/100 beats) | 56 ± 5 | 73 ± 4* | 52 ± 6 |
| MSNA (burst/min) | 32 ± 3 | 42 ± 3* | 28 ± 3 |
| MSNA (mean normalized amplitude) | 0.29 ± 0.04 | 0.36 ± 0.04* | 0.22 ± 0.04 |
| MSNA (normalized total MSNA) | 9.28 ± 1.41 | 15.70 ± 2.78* | 6.56 ± 1.83 |
| NE (pg/ml) | 323 ± 47 | 286 ± 39 | 275 ± 47 |
| E (pg/ml) | 40 ± 7 | 29 ± 4 | 31 ± 4 |
| Systolic BP (mmHg) | 116 ± 5 | 118 ± 6 | 117 ± 9 |
| Diastolic BP (mmHg) | 61 ± 3 | 65 ± 3 | 60 ± 3 |
| MAP (mmHg) | 83 ± 3 | 85 ± 4 | 82 ± 5 |
| Heart rate (bpm) | 59 ± 2 | 60 ± 3 | 57 ± 3 |
| Total plasma cholesterol (mmol/L) | 3.4 ± 0.4 | 5.5 ± 0.5* | 3.5 ± 0.4 |
| LDL (mmol/L) | 1.8 ± 0.4 | 3.5 ± 0.4* | 1.7 ± 0.2 |
| HDL (mmol/L) | 1.0 ± 0.1 | 1.0 ± 0.1 | 0.9 ± 0.1 |
| Triglycerides (mmol/L) | 1.4 ± 0.2 | 2.5 ± 0.4 | 2.4 ± 1.2 |
BP blood pressure, E arterial plasma epinephrine concentration, HDL high density lipoprotein, LDL low density lipoprotein, MAP mean arterial pressure, MSNA muscle nerve sympathetic activity, NE arterial plasma norepinephrine concentration
* P < 0.05 versus statin