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GTG-banded karyotypes of the benign and malignant fibroblast cells from a NF1 patient. (A) Normal karyotype, 46,XY, was detected in metaphases of the benign cells. (B) Abnormal karyotype of loss of Y chromosome, 45,X,-Y, was detected in metaphases of the malignant cells. Arrow indicates where loss occurred in the Y chromosome.
