. 2010 Jan;26(1):89–98. doi: 10.1089/aid.2009.0144

Table 2.

Comparisons of NAb Titers

		NAb assay in MT4 cells	NAb assay in TZM-bl cells
Observed		SHIV PBMCs	SHIV PBMCs	SHIV 293T	SHIV (Pseudo) 293T
Animal ID	Sterilizing protection	NAb titer in plasma (complete inhibition of spreading infection)	NAb titer in plasma EC₅₀ (SD)	NAb titer in plasma EC₅₀ (SD)	NAb titer in plasma EC₅₀ (SD)
98P049	Yes	1:123	1:332 (65)	1:2531 (580)	1:4074 (505)
98P031	Yes	1:123	1:413 (125)	1:1481 (117)	1:1812 (529)
98P043	Yes	1:40	1:117 (3)	1:820^a	1:1484 (11)
98P045	Yes	1:18	1:52 (24)	1:428 (94)	1:1015 (41)
98P046	No	1:18	1:66 (12)	1:371 (16)	1:843 (14)
98P023	Yes	1:15	1:54 (12)	1:430 (66)	1:854 (117)
98P021	Yes	1:13	1:36 (25)	1:201 (8)	1:375 (93)
98P061	Yes	1:12	1:195 (23)	1:392 (76)	1:417 (48)
98P082	No	1:7	1:177 (5)	1:275 (81)	1:278 (10)
98P042	Yes	1:6	1:30 (9)	1:68 (11)	1:92^a
96P076	No	1:3	1:5^b	1:55 (7)	1:96 (1)

Predicted		SHIV PBMCs	SHIV PBMCs	SHIV 293T	SHIV (Pseudo) 293T
Animal ID	Sterilizing protection	NAb titer in plasma (complete inhibition of spreading infection)	NAb titer in plasma (80% prediction interval for EC₅₀)^c	NAb titer in plasma (80% prediction interval for EC₅₀)	NAb titer in plasma (80% prediction interval for EC₅₀)
98P024	Yes	1:40	1:55–1:420	1:480–1:1272	1:1717–1:2230
94P011	Yes	1:8	1:14–1:109	1:107–1:284	1:158–1:491
98P035	No	1:7	1:13–1:97	1:95–1:251	1:139–1:433
94P040	Yes	1:5	1:10–1:73	1:69–1:184	1:101–1:315
94P028	No	1:4	1:18–1:61	1:56–1:149	1:82–1:256
96P088	Yes	1:4	1:8–1:61	1:56–1:149	1:82–1:256
96P081	No	1:4	1:8–1:61	1:56–1:149	1:82–1:256
94P032	No	1:3	1:6–1:48	1:34–1:114	1:63–1:195
94P029	No	1:3	1:6–1:48	1:34–1:114	1:63–1:195
94P027	No	1:3	1:6–1:48	1:34–1:114	1:63–1:195

^{^a}

An EC₅₀ neutralization titer was obtained from only one replicate.

^{^b}

Estimated EC₅₀; a 50% neutralization titer could not be obtained for either replicate.

^{^c}

80% predicted TZM-bl NAb titer intervals based on a linear regression model for animals for which plasma was no longer available (see Fig. 3).