Table 3.
Animal Protective Neutralizing Antibody Titers
| |
|
|
|
% Protection |
||||
|---|---|---|---|---|---|---|---|---|
| Assay | Virus | Animals (n) | p-Value | 99 | 90 | 80 | 50 | 33 |
| MT4 cell | SHIV PBMCs | 21 | 0.02 | 50 (24.7, 4.303)a | 20 (11, 249) | 14 (8, 79) | 7 (3, 14) | 5 (1, 8) |
| TZM-bl | SHIV PBMCs | 21 | 0.02 | 1096 (174, 2.8211) | 229 (73, 5.776) | 118 (45, 6.804) | 34 (2.5, 107) | 18 (<1, 46) |
| TZM-bl | SHIV 293T | 21 | 0.007 | 2204 (587, 7.126) | 661 (263, 5.144) | 398 (185, 6.983) | 151 (40, 365) | 93 (8, 192) |
| TZM-bl | SHIV (Pseudo) 293T | 21 | 0.009 | 4467 (978, 4.977) | 1175 (438, 1.775) | 676 (299, 1794) | 234 (53, 618) | 141 (8, 308) |
The NAb titers calculated from the augmented probit analyses shown in Figs. 2 and 4b are indicated in bold.
a
95% confidence interval.