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. 2010 Feb 1;137(3):457–466. doi: 10.1242/dev.045286

Fig. 5.

Fig. 5.

Hox regulation of col transcription at the progenitor stage is modular. (A,B,D-H) Lateral views of stage 11 Drosophila embryos expressing lacZ in the DA3/DO5 (A, arrowhead) and DT1/DO4 (A, arrow) progenitors under control of either the 4_0.9 or 2.6_0.9 CRM. (A,B) lacZ expression in T2 and T3 (horizontal bar) in wt embryos requires the 4_2.6 CRM. (D-F) 2.6_0.9-lacZ expression is induced in T2 and T3 by Ubx but not by Antp; 4_0.9-lacZ expression is induced by Antp in all segments, including in T1 (asterisk in D). (G) Mutation of the Hox2 site abolishes 2.6_0.9-lacZ expression in progenitors. (H) lacZ expression in the DA3 muscle at stage 15 is independent of the 4_2.6 CRM and Hox2. (C) Schematic of a stage 11 embryo with the Col-expressing progenitors shown as red dots and domains of mesodermal Antp and Ubx/AbdA expression as green and blue lines, respectively. Beneath are the 4_0.9-lacZ and 2.6_0.9-lacZ constructs showing the Antp- and Ubx-responsive elements in green and blue, respectively. Position of the Hox1 and Hox2 sites is indicated (see Fig. S4 in the supplementary material).