. Author manuscript; available in PMC: 2010 Apr 23.

Published in final edited form as: Toxicol Appl Pharmacol. 2008 Dec 9;235(2):143–152. doi: 10.1016/j.taap.2008.11.017

Table 1.

Biotransformation of fenthion and related metabolites in microsomal fractions isolated from liver, gills and olfactory tissues in freshwater-acclimated rainbow trout (Oncorhynchus mykiss)

Substrate (100 μM)	Metabolite	Tissue
Substrate (100 μM)	Metabolite	Liver	Gills	Olfactory tissues
Fenthion	Fenoxon	25.1±4.5	11.7±2.1	bdl
	S-fenthion sulfoxide	57.1±7.9	21.2±1.2	bdl
	R-fenthion sulfoxide	29.8±0.4	18.0±0.5	bdl
	S-fenoxon sulfoxide	bdl	bdl	bdl
	R-fenoxon sulfoxide	bdl	bdl	bdl
	MMTP (NADPH-independent)	7.5±3.2	133.5±5.8	71.2±11.1
	MMTP (NADPH-dependent)	145.9±4.4	117.5±9.5	240.2±28.0
Fenoxon	S-fenoxon sulfoxide	112.1±5.6	60.5±3.4	bdl
	R-fenoxon sulfoxide	38.4±0.9	21.7±6.3	bdl
	MMTP (NADPH-independent)	7.2±1.2	129.9±4.3	84.5±9.1
	MMTP (NADPH-dependent)	158.3±12.0	123.4±6.2	269.3±21.5
S-fenthion sulfoxide	S-fenoxon sulfoxide	6.1±0.2	2.3±0.2	bdl
R-fenthion sulfoxide	R-fenoxon sulfoxide	5.2±1.1	2.9±0.1	bdl

Data are presented as pmol/min/mg protein and as mean±SD (n=8 individuals for liver and gill; n=3 replicates for each pooled sample for olfactory tissue).

MMTP: 3-methyl-4-(methylthio)-phenol.

bdl: below detection limit (<0.3 pmol/min/mg protein).