. Author manuscript; available in PMC: 2010 Apr 23.

Published in final edited form as: Toxicol Appl Pharmacol. 2008 Dec 9;235(2):143–152. doi: 10.1016/j.taap.2008.11.017

Table 3.

Effects of hypersaline conditions on the in vitro biotransformation of fenthion in microsomes of liver from rainbow trout (Oncorhynchus mykiss)

Substrate	Metabolite	Treatment
Substrate	Metabolite	Freshwater	Hypersaline
Fenthion (100 μM)
	Fenoxon	20.5±2.2	42.2±4.1^**
	S-fenthion sulfoxide	59.6±4.5	298.1±22.4^**
	R-fenthion sulfoxide	27.6±2.5	138.3±12.4^**
	S-fenoxon sulfoxide	bdl	8.2±0.3^**
	R-fenoxon sulfoxide	bdl	3.4±0.4^**
	MMTP (NADPH-independent)	7.4±2.9	6.4±2.3
	MMTP (NADPH-dependent)	132.2±10.3	21.1±10.5^**
Fenoxon (100 μM)
	S-fenoxon sulfoxide	112.1±5.6	268.7±4.0^**
	R-fenoxon sulfoxide	38.4±0.9	106.8±2.2^**
	MMTP (NADPH-independent)	7.2±1.2	9.2±3.4
	MMTP (NADPH-dependent)	158.3±12.0	10.5±6.1^**
S-fenthion sulfoxide (100 μM)
	S-fenoxon sulfoxide	6.1±0.2	12.2±3.2^*
R-fenthion sulfoxide (100 μM)
	R-fenoxon sulfoxide	5.2±1.1	9.2±0.3^*

Data are expressed as pmol/min/mg protein and as mean±SD (n=8). Significant differences with respect to freshwater-acclimated rainbow trout indicated by ^* (P<0.05; Student’s t-test) and ^** (P<0.01; Student’s t-test).

MMTP: 3-methyl-4-(methylthio)-phenol.

bdl: below detection limit (<0.3 pmol/min/mg protein).